Let's examine one study with Shaklee's Vivix, a patented blend of resveratrol and muscadine grape polyphenols.
This was a completely independent study conducted by Dr. Paresh Dandona and his colleagues at the State University of New York at Buffalo and published in the Journal of Clinical Endocrinology & Metabolism (H. Ghanim et al, J. Clin. Endocrin. Metab., doi:10.1210/jc.2010-1812) and available online. The fact that it is an independent study is important. That means that Shaklee didn't control the data. If Vivix had turned out to be no better than a placebo, those would have been the results that would have been published!
In this study a group of young, healthy, normal-weight adults were fed a typical fast food breakfast of egg muffin and sausage sandwiches and two servings of hash browns. That's a whopping 910 calories with 51 grams of fat (1/3 of that saturated), 88 grams of carbohydrate and 34 grams of protein!
In a previous study (Ghanim et al, Diabetes Care, 32: 2281-2287, 2009) Dr. Dandona had shown that a fast food meal like that turns on genes that cause a massive increase in reactive oxygen species (ROS). The increase in ROS then activates a number of genes that trigger an inflammatory response - including two genes, SOCS-3 and TLR-4, that are thought to interfere with insulin signaling (which can lead to insulin resistance) and damage to the walls that line the arteries (As you might imagine, neither of those responses is good). And, if that weren't enough SOCS-3 also interferes with the leptin signaling pathway. Simply put, interference with the leptin signaling pathway means that your brain doesn't realize that you just ate 910 calories, so you will probably want to eat more.
Now we do have a gene called Nrf-2 that is supposed to be turned on when reactive oxygen species are detected. It, in turn, activates a number of antioxidant genes that will neutralize the reactive oxygen species and protect our cells from oxidative damage. In the cruelest blow of all the fast food meal turns off Nrf-2 and all of the antioxidant genes that it controls.
With that as background... let's look at this new study.
Dr. Dandona choose to use the fast food experimental model because fast food meals give such a dramatic response in such a short period of time that it’s easy to test whether a given food or supplement can prevent inflammation and oxidative damage.
Dr. Dandona simply gave one group Vivix, and one group a placebo, 10 minutes before the fast food meal. As you might suspect, the placebo did not alter any of the bad effects of the fast food meal.
However, when Vivix was taken just prior to the fast food meal:
- The genes that generate free radicals were NOT turned on.
- The genes that trigger the inflammatory response were NOT turned on.
- SOCS-3 and TLR-4 were NOT turned on
- Nrf-2 and the antioxidant genes it controls WERE turned on.
In other words, Vivix completely reversed the short term bad effects of the fast food meal.
So what does this mean for you? Should you take a Vivix chaser with your next fast food meal? Perhaps, but think how much Vivix could do for you if you ate a good diet!
Sadly, even if you don't eat fast food meals you should know that oxidative damage, chronic inflammation and insulin resistance have many causes. You don't need to eat a fast food meal to generate that kind of metabolic stress.
And it would be foolish to think that Vivix could undo all of the bad effects of fast foods. Vivix simply prevents the immediate effects of a fast food meal. If you continue to eat fast foods on a regular basis you will pack on the pounds, plug your arteries, raise your blood pressure, etc., etc.
But, to me the most important conclusion from this clinical study is that Vivix works. It gets into your bloodstream and turns off the genes that need to be turned off, and turns on the genes that need to be turned on.
In the marketplace, you will find many resveratrol products, and of course, all of those companies make claims for their products, but unless they have a published clinical study, they have no proof that their product actually works!
Shaklee... Always Safe, Always Works... with clinical studies to prove it!
Ask about additional studies... Shaklee has over 100 Published Peer-Reviewed studies on their products.